Marilynn Vetzel Selected Research

EC145

12/2018	Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic.
1/2016	High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide.
4/2014	Rational combination therapy of vintafolide (EC145) with commonly used chemotherapeutic drugs.
3/2014	Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship.
2/2011	Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications.
9/2009	In vivo structural activity and optimization studies of folate-tubulysin conjugates.
10/2007	Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145.
5/2007	Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Marilynn Vetzel Research Topics

Disease

21	Neoplasms (Cancer) 01/2020 - 11/2002
3	Weight Loss (Weight Reduction) 01/2019 - 05/2007
1	Osteosarcoma (Osteogenic Sarcoma) 01/2019
1	Prostatic Neoplasms (Prostate Cancer) 01/2019
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019
1	Lung Neoplasms (Lung Cancer) 01/2016
1	Constipation 02/2011
1	Lymphoma (Lymphomas) 05/2007

Drug/Important Bio-Agent (IBA)

16	Folic Acid (Vitamin M)FDA LinkGeneric 01/2019 - 11/2002
8	EC145IBA 12/2018 - 05/2007
7	Pharmaceutical PreparationsIBA 01/2020 - 09/2007
4	LigandsIBA 01/2019 - 12/2006
4	tubulysin BIBA 01/2019 - 12/2008
4	Biological ProductsIBA 01/2019 - 07/2005
4	AlkaloidsIBA 12/2018 - 02/2011
3	EC0305IBA 06/2017 - 12/2008
2	Fluorescein-5-isothiocyanate (FITC)IBA 01/2019 - 12/2006
1	DNA (Deoxyribonucleic Acid)IBA 01/2020
1	isothiocyanic acidIBA 01/2019
1	Docetaxel (Taxotere)FDA Link 01/2019
1	Chimeric Antigen ReceptorsIBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	AntigensIBA 01/2019
1	Fluorescein (Funduscein)FDA LinkGeneric 01/2019
1	Cisplatin (Platino)FDA LinkGeneric 12/2018
1	Paclitaxel (Taxol)FDA LinkGeneric 12/2018
1	EC0531IBA 06/2017
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2016
1	HydrazinesIBA 01/2016
1	EC 0489IBA 02/2011
1	EC0225IBA 09/2007
1	Therapeutic UsesIBA 07/2007
1	Blocking AntibodiesIBA 12/2006
1	HaptensIBA 12/2006
1	Neoplasm Antigens (Tumor Antigens)IBA 12/2006
1	AntibodiesIBA 12/2006
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 07/2005

Therapy/Procedure

10	Therapeutics 01/2019 - 09/2006
1	Drug Therapy (Chemotherapy) 01/2019
1	Immunotherapy 12/2006
1	Duration of Therapy 12/2006